Yang et al’s

[34] 2-year study of 5346 patients presenting to one hospital in Guangzhou following injury used a registry log as the data source. Mechanism was reported and while the descriptive categories were similar, the injury cause profile differed from all other studies with cutting/piercing being the most common injury mechanism (41%) (Table ​(Table7).7). No information concerning OSI-906 patient occupation or location of injury Inhibitors,research,lifescience,medical was presented. The age categories included children and youth combined (0-15), then used deciles with the upper category being 61+ years; none of the studies in this Review categorised older adults in detail with age being capped in the mid-60′s or being 60+ years. Reliance on the initial registry log meant that only nine deaths were recorded, with the ISS being recorded only for these patients (0.3%), presumably Inhibitors,research,lifescience,medical due to later examination or autopsy, although this was unclear. The patient series presented by Wen et al [35] was a pre-post comparison on the establishment

of a dedicated emergency trauma department. The ‘pre-period’ Inhibitors,research,lifescience,medical was 1 January 1996 to 31 December 1997 with patients being assigned to a surgical department for care (i.e., usual care). The ‘post-period’ was 1 January 1998 to 1 January 2004 (75% of patients), with patients treated within a dedicated trauma department. The study captured 8271 patients, of which 53.3% (4416) were injured in road traffic crashes (Table ​(Table5,5, ​,7).7). Age was reported as a mean and a range, while gender, mortality and injury mechanism were also reported. The study reported AIS for patients with an isolated injury (the only study to use AIS in the Review) and ISS for multi-trauma patients.

Inhibitors,research,lifescience,medical For patients in the ‘pre’ trauma service period 74% (1269 of 1715) had an AIS ≥ 3 injury compared to 77% (3998 of 5192) AIS ≥ 3 injuries in the ‘post’ period. For the multi-trauma patients, 69% (220 of 318) of patients in the pre-period had an ISS > 15 in contrast to 86% (902 of 1046) of those in the ‘post’ Inhibitors,research,lifescience,medical period. The establishment of the trauma service resulted in a significant reduction in a range of key process Non-specific serine/threonine protein kinase and outcome indicators (Table ​(Table8).8). This study is important as it provides evidence that the formation of a dedicated trauma service provides superior care on these performance metrics. The ability to report these findings clearly demonstrates the value and importance of collection and analysis of registry data. In this context it is worth commenting that the purpose of this study was to evaluate trauma system change rather than the surveillance nature of the other studies in this Review, and hence the greater emphasis being placed on the collection of treatment processes and clinical outcomes than in the other studies reported in this Review.