The clients had been analyzed at the Clinic for the psychological state Research Center throughout the period 2020-2023. The mean age the customers ended up being 19±4.1 years. Based on the information from studying despair and NSSI in adolescence, we created a typology, distinguishing three variants of affect and auto-aggressive task interactions. The affect-dominant kind (25.8%) ended up being described as a predominance of affective pathology ( <0.05). The personality-dominant type (43.0%) was considering pathocharacterological abnormalities (60.0%), where NSSI wereof their particular interrelation had been revealed. The outcome can be viewed as as differential diagnostic and prognostic markers of these additional trajectories and, therefore, play a role in the creation of new healing techniques, appropriate analysis and previous intervention.Three forms of correlation between depression and NSSI had been identified, the formation of which was as a result of the pathoplastic impact for the age aspect, nosological affiliation and a specific, including pathological personality framework. Statistically significant regularities between variants of NSSI and kinds of their particular interrelation were uncovered. The outcome can be considered as differential diagnostic and prognostic markers of the further trajectories and, therefore, play a role in the development of brand new healing techniques, prompt analysis and earlier in the day input. To examine psychopathological construction characteristics of depersonalization depression in ladies and nonsuicidal autoaggressive and suicidal behavior faculties in these states. =30) using the predominance of planned committing suicide efforts over impulsive people; considerable frequency and selection of nonsuicidal self-harm utilizing the predominance of «depersonalizing» motives because of its payment. To determine the clinical and psychopathological options that come with existential despair in childhood. 53 male patients (16-25 yrs . old) with analysis F31.3, F31.4, F32, F33 with existential motifs of depressive experiences were studied by clinical and psychopathological method. The axial symptom of existential ended up being over-value some ideas about the meaninglessness of their own and human life with tips of self-abasement, insolvency, low value, imperfection of society, which in most regarding the studied cases (79.2per cent) had been accompanied by various degrees of extent suicidal ideas and motives. Three types were identified utilizing the prevalence of reflections regarding the meaninglessness of life (39.6%); with all the prevalence of neurotic religiosity (28.3%); with an existential philosophical explanation (32.1%). As a consequence of the research, the heterogeneity of existential depressions, a significant role of psychogenic elements within their development were revealed, as a top suicidal risk. Existential depressive states differed in length of time, seriousness of depressive signs, high-frequency of non-suicidal self-neglect and suicidal danger.Because of the study, the heterogeneity of existential depressions, a significant part of psychogenic facets in their formation had been uncovered, as a high suicidal danger. Existential depressive states differed in length of time, severity of depressive symptoms serum biomarker , high frequency of non-suicidal self-neglect and suicidal threat. To look for the degrees of pro-inflammatory and anti inflammatory cytokines and inflammatory markers such as for instance C-reactive protein, leukocyte elastase, α1-proteinase inhibitor, autoantibodies to neuroantigens into the bloodstream of customers with adolescent depression with clinical high risk for psychosis (CHR-P) and also to learn the relation of those biological markers towards the attributes of psychopathological symptomatology regarding the patients. Eighty youngsters, elderly 16-24 many years, because of the first depressive event (F32.1-2, F32.38, F32.8) had been studied. On the basis of the existence of attenuated positive symptoms within the structure of depression, all clients were split into two teams with CHR-P (clinical group, =22). The HDRS-21, SOPS, and SANS were utilized for psychometric assessment regarding the patients MLN2238 . Serum levels of cytokines TNF-α, IL-6, IL-8, IL-10, and focus of C-reactive protein (CRP) had been determined. Leukocyte elastase (LE) task, α1-proteinase inhibitor (α1-PI) activitflammatory markers in despondent patients recommend an even more pronounced pro-inflammatory potential into the team with CHR-P. To guage the effectiveness and safety of escitalopram in the shape of oral dispersible tablets (Elicea Q-Tab) in real-life clinical rehearse in customers with depressive and anxiety problems. The study included 1.892 outpatient patients, 1.860 of whom completed involvement according to the protocol and entered the analytical evaluation. Many customers had been clinically determined to have depressive and anxiety disorders of varying extent, as a rule, these diagnoses were set up for the first time. The drug had been oftentimes recommended at a dosage of 10 mg/day. The patients had been administered for 90 days and also at each one of the 3 visits, scales were utilized to assess the clinical condition (CGI-S and CGI-I), machines «Interaction with people, maintaining interactions (personal functioning)» and «Availability of work, task conclusion, college attendance (professional performance feline toxicosis )», scales pleasure with all the capability of admission/appointment and also the effectiveness of therapy, different indicators of standard of living (autonomynxiety problems in real-world clinical options.