2-1.9; P = .0019).

Conclusions:

Multicenter analysis confirms that a history of multiple previous percutaneous coronary interventions increases in-hospital mortality and the incidence of major adverse cardiac events after subsequent coronary artery bypass grafting. Critical discussion of the treatment strategy in these patients is warranted.”
“Objective: The relationship between previous percutaneous coronary intervention and perioperative outcome after coronary artery bypass grafting remains undetermined. The aim of the study was to investigate whether previous elective percutaneous coronary intervention influences the outcome of elective coronary artery bypass grafting.

Methods: Between 2002 and 2007, 4412 consecutive patients underwent learn more first-time open surgery at the Innsbruck Medical University. After excluding patients with a history of emergency percutaneous coronary intervention, we isolated 306 patients with elective percutaneous coronary intervention during the last 24 months before isolated coronary artery bypass grafting (group 1). Those patients were compared with 452 consecutive age-, gender-, and EuroSCORE-matched patients without a history of percutaneous coronary intervention (group 2), in terms of 30-day mortality, major adverse cardiac events,

and perioperative complications.

Results: Both groups were comparable concerning preoperative linear EuroSCORE (group 1: 4.83 Selleck Capmatinib +/- 0.18, group 2: 4.72 +/- 0.14, P = .63). Patients who underwent previous elective percutaneous

coronary intervention before Selleckchem VX-661 coronary artery bypass grafting had an increase in perioperative mortality (group 1: 4.4% vs group 2: 2.4%, P <. 001) and major adverse cardiac events (group 1: 7.9% vs 4.3%, P <. 001). In addition, the incidence of bleeding complications (group 1: 5.9% vs group 2: 3.8%, P = .017) and the number of blood products (group 1: 1.70 +/- 0.31 vs 0.61 +/- 0.17, P <. 001) used were higher in patients of group 1. A higher incidence of acute renal failure (5.9% vs 2.7%, P = .025) and renal replacement therapy (3.6% vs 1.7%, P = .03) was observed in patients of group 1.

Conclusion: Patients with a history of elective percutaneous coronary intervention before referral to coronary artery bypass grafting have a worse perioperative outcome in terms of mortality, major adverse cardiac events, and perioperative complications compared with patients without a history of percutaneous coronary intervention. This fact should be considered in risk stratification for patients who are scheduled for elective coronary artery bypass grafting.”
“Objective: We sought to identify changes in four-and-a-half LIM-protein 2 levels and location in human cardiomyocytes during the transition from compensated aortic stenosis to left ventricular failure.