8 (1.9–149.0) 4.0 (1.9–22.0) 8.4 (3.7–41.0) 0.523 0.002 1wAE 5.9 (1.9–57.0) 3.7 (1.9–32.0)

–   0.273   4wAE 7.0a (1.9–141.0) 3.1 (1.9–11.0) 28.0 (1.9–200.0) 0.050 0.002 a1wAE ↔ 4wAE P = 0.050 Specific nasal JNK inhibitor challenge At the specific nasal challenge in the S+ group, the total nasal symptom score before challenge increased from 1 before work started find more to 2 after 4 weeks (Median; P = 0.022). After the first challenge, the symptom score increased from 1 to 2 (P = 0.005) and after 4 weeks of exposure the score increased from 2 to 3 (P = 0.006) indicating no change in nasal reactivity. The sub-group of those who reacted significantly at the first challenge did not react more at the Berzosertib research buy second challenge compared to the non-reactors. No significant changes were found in acoustic rhinometry (data not shown). Before work started, albumin increased significantly from baseline to after the second challenge,

while after 4 weeks of work the same increase was not significant (Table 5). Table 5 Albumin (mg/L) and Substance P (µg/L) (median; range) in nasal lavage fluid at specific challenge with per sulphate in symptomatic hairdressers (n = 17) after vacation and after four weeks of exposure   BE AE Albumin (mg/L)  Time 0 4.2 (0.3–57.0) 4.7 (0.6–22.0)  Baseline 2.0 (0.6–17.0) 2.4 (0.3–14.0)  20 Cyclin-dependent kinase 3 min after challenge 2 4.0a (0.5–19.0) 3.7 (0.3–11.0) Substance P (µg/L)  Time 0 9.5 (4.3–44.4) 12.2 (6.4–34.8)  Baseline 8.9 (0.0–29.3) 12.6 (4.2–33.0)  20 min after challenge 2 10.9b (3.9–60.7) 12.1 (3.9–40.6) BE before and AE after four weeks of exposure P value: a 0.047 baseline ↔ after challenge 2, b 0.030 baseline ↔ after challenge 2 Health-related quality of life Summary indexes Before the exposure, the S+ and the PA groups had approximately the same Overall QoL. The S− had a better score

compared to the other two groups (Table 6). After the study period, the hairdresser groups did not change significantly, whereas the PA group was significantly worse with a mean difference of 0.8. In the SF 36 before the study, the two hairdresser groups did not differ and had a higher score than the PA group in the mental summary score, though not significantly. No significant changes were noticed within the groups after the observation period (data not shown). During the exposure period, two S+ and one S− hairdressers as well as one participant from the PA group had experienced personal problems. Two S+ hairdressers had developed eczema to hairdresser chemicals. These events did not influence the results of the questionnaires, which we tested for by analyzing and comparing the data including and excluding these persons.