Enrollment criteria included the following: 26 to 73 (median: 55) years of age; baseline serum HCV-RNA quantified by RT-PCR between 3.9 and 7.4 log copies/ml; and infection with HCV genotype 1 (n = 68) or 2 (n = 71). All patients (98 males and 41 females) were treated with pegylated Selleckchem BGB324 (PEG)-IFN alpha-2a alone, or PEG-IFN alpha-2a or PEG-IFN alpha-2b in combination with ribavirin. A negative result for serum HCV-RNA on RT-PCRat the assessment

point was defined as sustained virological response (SVR). Serum BTR, BCAA and Tyr were determined both at baseline and at the assessment point. Of 139 patients, 121 underwent liver biopsy before starting therapy, and the tissue specimens obtained were graded according to the Histology Activity Index (HAI) of Knodell et al. Specimens buy BVD-523 were also divided into four groups from stages 1 to 4 based on Desmet’s fibrosis scores. Of 139 patients, 51 consented to genetic investigation for polymorphisms in the interleukin (IL)-28B gene at rs8099917. Results: Serum BTR tended to decrease and serum Tyr tended to increase with grade or stage. Additionally,

49 of 68 CHC patients infected with genotype 1 and 66 of 71 CHC patients infected with genotype 2 showed SVR. In SVR patients, serum BTR was significantly. Conclusion: This study showed that, if HCV was eradicated from the liver in CHC patients infected with genotypes 1 and 2, BTR increased with reductions in serum Tyr levels. Key Word(s): 1. chronic hepatitis

C; 2. BTR Presenting Author: WON SOHN Additional Authors: YONG HAN PAIK, DONG HYUN SINN, GEUM YOUN GWAK, MOON SEOK CHOI, JOON HYEOK LEE, KWANG CHEOL KOH, SEUNG WOON PAIK, BYUNG CHUL YOO Corresponding Author: WON SOHN Affiliations: Samsung Medical Center, Samsung Medical Center, Samsung Medical Center, Samsung Medical Center, Samsung Medical Center, Samsung Medical Center, Samsung Medical Center, Samsung Medical Center Objective: Recent studies have shown that antiviral therapy may reduce the recurrence of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV). This study was aimed to investigate the effect of virologic response to MCE公司 anti-viral therapy on the recurrence after curative resection in patients with HBV-related HCC. Methods: Between January 2008 and December 2010, a total of 72 antiviral therapy naïve patients underwent curative resection for HBV-related HCC (single nodule; <5 cm in diameter, or multi-nodule; number ≤3 and diameter <3 cm). All patients were treated with antiviral therapy within 1 month after resection (entecavir, 58; clevudine, 11; lamivudine, 3 patients). We assessed the risk factors for recurrence of HCC after curative resection. Complete virologic response to anti-viral therapy was defined as undetectable HBV DNA (9 IU/mL). Results: The median follow-up duration was 41.7 months.