inhibition of PI3K Akt mTOR signaling offers promising methods of prevention and treatments for prostate cancer. mTOR types two functional processes, C1 and C2, and integrates signals from cellular energy status, growth factors, and nutritional elements to regulate cell growth and proliferation by regulating protein synthesis. Phosphorylation of mTOR at Ser2448 by Akt or S6K1 and at Ser2481 by automobile phosphorylation is important for the activity. The activity of mTOR is negatively controlled by tuberous reversible HDAC inhibitor sclerosis complex 1 and 2. MTOR activation is inhibited by tsc1/tsc2 complex dissociates Ras homolog enriched in brain from mTOR, thus. Akt phosphorylates TSC2 and disrupts the TSC1/ TSC2 complex, leading to activation of mTOR. On the other hand, 5 AMP activated protein kinase, that will be activated by increased AMP/ATP ratio and/or cyst suppressor LKB1, inhibits mTOR activation by activating TSC1/TSC2. Triggered mTOR C1 phosphorylates the translation inhibitor 4e-bp1 and the ribosomal protein S6 kinase, in initiation of protein translation. p70 S6K also phosphorylates and inhibits insulin receptor substrate 1, forms a poor feed back regulation of PI3K/Akt signaling. The PI3K/Akt/mTOR process can be controlled by serine/threonine protein phosphatases. Two main courses of serine/threonine RNA polymerase protein kinases, PP1 and PP2A, are extensively associated with several signaling pathways. It’s been well documented that PP2A interacts with and dephosphorylates Akt in vitro and in vivo. PP2A has additionally been noted to dephosphorylate S6K in response to different stimuli. Furthermore, 4e-bp1 has been defined as a substrate of PP2A in vitro and in vivo. Currently no direct evidence proves that mTOR is dephosphorylated by PP2A. However, research using adenovirus recommended Lonafarnib SCH66336 that mTOR activity is regulated by PP2A, and mTOR can also be mixed up in regulation of PP2A activity. Compare to PP2A, PP1 is less involved with Akt/mTOR signaling, probably due to the absence of PP1 recognition sequences and docking motifs in the main components of Akt/mTOR signaling. Besides PP2A and PP1, PH domain leucine wealthy repeat protein phosphatase 1 and 2 have been recognized as unique Akt S473 phosphatases In many human tumors, particularly prostate cancers, PI3K/Akt/mTOR signaling is dysregulated by numerous oncogenic events. The hormone refractory prostate cancers are generally seen as an inactivation of PTEN and activation of Akt/mTOR signaling. Akt activity is an crucial determinant of the sensitivity of prostate cancer cells to treatments. Curcumin, a significant chemical element of turmeric, possess a broad-spectrum of therapeutic and chemopreventive properties against various cancers in both in vitro and in vivo models and clinical trials. Curcumin has been shown to inhibit cell growth, produce apoptosis, reduce inflammation, and sensitize tumor cells to cancer treatments.