Our objective was to test whether palivizumab prophylaxis given to preterm infants during the first RSV season reduces the incidence of subsequent recurrent wheezing up to 3 years of life.\n\nMETHODS: Dibutyryl-cAMP ic50 We conducted an observational prospective multicenter (52 registered hospitals in

Japan) case-control study in preterm infants with a gestational age between 33 and 35 weeks followed for 3 years. During the 2007-2008 RSV season, the decision to administer palivizumab was made based on standard medical practice. In April 2008, 52 hospitals were recruited. Study participants were prospectively followed to the age of 3 years. Parents of study subjects reported the infants’ physician’s assessment of recurrent wheezing,

used a report card and a novel mobile phone-based reporting system by using the Internet. The primary end point was the incidence of physician-diagnosed recurrent wheezing.\n\nRESULTS: Of 444 preterm infants enrolled, 349 received palivizumab during the first 6 months of life and 95 infants did not. Physician-diagnosed recurrent wheezing was observed in 6.4% and 18.9% of infants in the treated and untreated groups, respectively (P < .001). This difference remained significant after adjustment for known risk factors of recurrent wheezing (P < .001).\n\nCONCLUSIONS: Palivizumab prophylaxis administered to preterm infants 33 to 35 weeks’ gestational SB202190 age is associated with a significantly lower incidence of recurrent wheezing during the first 3 years of life.”
“Objective: This article describes the design of and difficulties inherent in the execution of a long-term, observational trial that sought

to assess the validity of short-term measures of multiple sclerosis (MS) (eg, relapse rate, inflammatory lesions) for long-term disease outcomes.\n\nMethods: In the original double-blind, placebo-controlled interferon (IFN)-beta 1b study, 372 patients with relapsing-remitting MS (Expanded Disability Savolitinib research buy Status Scale score 0.0-5.5) were randomly assigned to IFN-beta 1b 50 mu g (n = 125), IFN-beta 1b 250 mu g (n = 124), or placebo (n = 123) for 2 years. These patients were recruited 16 years later for participation in this long-term follow-up (LTF) study, which had no exclusion criteria or drug interventions.\n\nResults: The 11 centers identified 88.2% (328/372) of the original study patients at LTF; however, 10.8% (n = 40) refused to participate and 9.4% (n = 35) were deceased. Detailed evaluations were available for 260 patients, which included 7 deceased patients. No differences in demographic or baseline disease characteristics were found between individuals who did and did not participate in the LTF. More patients randomly assigned to placebo in the original trial were deceased (20/123 [16.3%]) than those assigned to IFN-beta 1b 50 mu g (9/125 [7.2%]; uncorrected P = 0.044) or IFN-beta 1b 250 mu g (6/124 [4.8%]; uncorrected P = 0.