Such morphology might be attributed to the plasticisation effect exerted by POL, resulting in the reduction of crystallinity and subsequent enhancement in overall amorphous fraction of the extrudates.11 FT-IR spectrum

of ACT (Fig. 2) showed N H stretching doublet of N H bands at 3180.0 cm−1 and 3096.2 cm−1 resulting from symmetrical and asymmetrical stretching, a medium Stem Cell Compound Library cell assay intensity, free C O stretching band at 1681.7 cm−1, a medium intensity band at 1402 cm−1 and a broad, medium intensity band in the range 800–666 cm−1 corresponding to C N stretching and plane N H wagging, respectively, a strong band at 3302.5 cm−1 due to a C H stretching vibration. Characteristic bands in the range of 1100–900 cm−1 pointed towards crystalline

polymorphic form A of ACT.12 For EPO (Fig. 2), the characteristic bands were observed at 1147.7, 1238.3, 1269.2, 1730.2 cm−1 corresponding to the ester groups, at 1388.8, 1450–1490 and 2949.3 cm−1 corresponding to the CHx vibrations and at 2769.9 and 2820.0 cm−1 corresponding to the dimethylamino groups. It could be observed from the FT-IR spectra of ACEU and ACEL (Fig. 2) that the principal bands were broadened and weaker in intensity compared to those observed in the spectrum MLN0128 in vivo of ACT. Also a broad and less intense band at about 3600 cm−1 suggested intermolecular hydrogen bonding in solid dispersions. Lowered frequency of C O stretching band suggested

involvement of a carbonyl group of amide in hydrogen bonding. Such pattern of FT-IR spectra of solid dispersions also provided a slight hint of formation of amorphous system.13 ACT was found to decompose at about 240 °C as evidenced by significant weight loss (12.14%) Astemizole during TGA analysis (Fig. 3). DSC analysis of ACT (Fig. 3) showed a sharp endotherm of enthalpy 511.5 J/g in the range of 258–262 °C corresponding to its melting, which was accompanied by decomposition as indicated by the exothermic peak. It was apparent from the TGA analysis (Fig. 3) that ACEU began to decompose at about 208 °C, exhibiting rather a sharp weight loss compared to ACT. DSC thermograms of ACEU(1:1) and ACEU(1:2) in Fig. 3 exhibited decreased enthalpy values (66.9 and 36.6 J/g, respectively) suggesting a partial loss of crystallinity of ACT and lowered onset temperature (about 205 °C) suggesting occurrence of an intramoleular hydrogen bonding between EPO and ACT. In systems comprising POL, the DSC thermograms (Fig. 3) showed presence of only one Tg with much decreased enthalpy. Such pattern and visual inspection of the extrudates suggested that incorporation of a plasticiser to the blend of ACT and EPO formed a single phase system on melt extrusion. In other words, the components were completely miscible on a molecular basis.