The only independent predictive risk factor is the baseline preoperative hemoglobin level. Patient requiring P-RBC transfusions had more complications in terms of higher infections and hemodialysis need, prolonging ICU and hospital stays. Maximum efforts must be focused on developing novel strategies for improving hemoglobin levels enzyme inhibitor during waiting list time to improve early outcome Inhibitors,Modulators,Libraries after transplantation. Conflict of Interests The authors of this paper have no conflict of interests to disclose. Acknowledgment Nicol��s Goldaracena is an HPB and Liver Transplant Fellow at Hospital Alem��n of Buenos Aires and has financial support Inhibitors,Modulators,Libraries from the Argentinean Liver Cancer Foundation (Fundaci��n Argentina C��ncer de H��gado).

Abbreviations LT: Liver transplant RBCs: Red blood cells HCC: Hepatocellular carcinoma FFP: Fresh frozen plasma P-RBC: Perioperative red blood cells ICU: Intensive care unit MELD: Model for end-stage liver disease CVP: Central venous pressure AST: Aspartate aminotransferase ALT: Alanine aminotransferase Inhibitors,Modulators,Libraries PNF: Primary nonfunction PDF: Primary dysfunction HCV: Hepatitis C virus BMI: Body mass index RCT: Randomized controlled trials.
Hepatitis C virus (HCV) infection is the most common cause of hepatocellular carcinoma (HCC) in the USA, Europe, and Japan, accounting for 47%�C49%, 56%, and 75% of cases, respectively [1, 2]. HCC causes >600,000 deaths annually worldwide and is the most common primary liver cancer [3]. Definitive treatment for HCC is surgical resection when possible or liver transplantation for patients with end-stage liver disease and liver tumors.

In USA, transplant guidelines stipulate that Inhibitors,Modulators,Libraries eligibility for liver transplantation is determined by the patient’s liver tumor(s) meeting the Milan criteria (a single tumor ��5cm in diameter or up to 3 tumors with individual diameters ��3cm and no macrovascular invasion) [4]. Unfortunately, the recurrence of HCC is a major cause of mortality in surgically treated patients [5]. There is no standard therapy for patients who are at high risk for HCC recurrence. Hence, a better understanding of the molecular mechanisms involved in the recurrence of HCC post LT is necessary to develop an efficient surveillance Inhibitors,Modulators,Libraries protocol and seek new potential therapies. Gene expression profiling is best performed on fresh or frozen tissue to lessen the degradation of RNA.

However, collecting and storing this tissue are burdensome AV-951 and costly, and obtaining Institutional Review Board (IRB) approval for longitudinal studies can be unsuccessful. Sample sizes are typically small, and collection requires years of time. In contrast, all clinical pathology laboratories have huge storage files containing formalin-fixed paraffin-embedded (FFPE) tissue. Formalin fixation has been used for several decades for preserving tissue. FFPE tissue would supply a huge resource for genomic studies to utilize previously collected samples with long-term clinical records.