It is suggested that ADPKD may be a predisposing factor for spontaneous coronary artery dissection.”
“Purpose of reviewThe assumption that patients with an extended duration of type 1 diabetes mellitus (T1D) do not retain residual functional cells and endogenous insulin production has recently been challenged. The purpose to this review is to highlight some of the key emerging evidence supporting residual insulin and C-peptide

secretion in long-standing T1D.Recent findingsRecent investigations conducted in a group of type 1 diabetics of long-term duration, characterized clinically and histologically, provided solid evidence to suggest that pancreatic cells are still present even after 50 years

in a majority of these individuals. These residual SIS3 concentration cells can secrete insulin in a physiologically regulated manner. Several published reports showed promising effects of glucagon-like peptide 1 (GLP-1) agonists on the glycemic control and residual C-peptide production in long-term T1D, although prospective studies are needed to rule out the potential long-term adverse effects of these drugs.SummaryC-peptide is no longer considered an irrelevant by-product of insulin biosynthesis. In-depth basic and translational investigations aimed at understanding the molecular immunology and the pathophysiology are needed to elucidate the mechanisms underlying the residual insulin and C-peptide production in long-term T1D. This may shed light on to the regenerative capacity of cells, RG7420 the genetic susceptibility of the mechanisms of resistance to -cell destruction, and possibly identifying new therapeutic strategies for T1D. Studies evaluating the long-term effects of insulin secretogogue agents along with immune intervention hold promise for their use in future clinical trials for long-term T1D.”
“Objective: To evaluate the clinical value of neonatal brain tissue segmentation in preterm infants according to the literature. Methods: A structured

literature search was undertaken in MEDLINE/Pubmed. This included all publications on volumetric brain tissue assessment in preterm infants at term-equivalent Milciclib age (TEA) compared to brain tissue volumes of term-born infants, related to perinatal risk factors or related to neurodevelopmental outcome. Results: Sixteen prospective cohort studies, described in 30 articles, fulfilled the criteria. Preterm infants displayed total and regional brain tissue alterations compared to healthy, term-born controls. These alterations seemed more prominent with decreasing gestational age. White matter injury, intraventricular haemorrhage, postnatal corticosteroid therapy, intra-uterine growth retardation and chronic lung disease were frequently associated with volume changes.