Methods: We performed a cohort study of patients with liver cirrhosis who contracted PHI and were treated at our institution between January 1990 and December 2004.
Results: Of 349 first-time episodes of PHI during the study period, 33 (9.5%) occurred in patients with liver cirrhosis. Debridement with retention of the prosthesis (DWROP) was the initial treatment modality for 24 (73%) episodes of PHI and cured the infection in seven (29%). A shorter median duration of symptoms (5 vs. 14 days; p = 0.007) and absence of a sinus tract (p = 0.02) were associated with successful treatment. Excision arthroplasty (EA) was required
in 26 (79%) episodes and eradicated PHI in 24 (92%). In 20 patients who had reimplantation Elafibranor clinical trial of a new prosthesis, the infection recurred in six (30%). Patients who developed hepatic decompensation after reimplantation had a significantly higher risk of recurrent PLX4032 ic50 PHI than those who did not (relative risk 7.5; 95% confidence interval 4.8-9.5; p = 0.018).
Conclusions: Liver cirrhosis is a common co-morbidity in patients with PHI treated at our institution. DWROP
should be considered only when there is no sinus tract and the duration of symptoms is very short (less than 10 days). EA is an effective procedure to cure infection. However, reimplantation of hip prosthesis in these patients carries a high risk of infection recurrence, especially in those who develop hepatic decompensation. (C) 2010 International Society for Infectious Diseases. Published by
Elsevier Ltd. All rights reserved.”
“Purpose: To directly compare the sensitivity of 64- section multidetector computed tomography (CT) with that of 1.5-T magnetic resonance (MR) imaging in the depiction and measurement of heterogeneous 7-8-week-old microinfarcts and the quantification of regional left ventricular (LV) function and perfusion in the territory of coronary intervention in a swine model.
Materials and Methods: Approval was obtained from the institutional animal committee. An x-ray/MR system was used to catheterize Nutlin-3 in vitro the left anterior descending (LAD) coronary artery with x-ray guidance and to delineate the perfusion territory. The vessel was selectively microembolized in six pigs with small-diameter embolic material (40-120 mu m, 250 000 count). At 7-8 weeks after microembolization, multidetector CT and MR imaging were used to assess LV function, first-pass perfusion, and delayed contrast enhancement in remote myocardium and microinfarct scars. Histochemical staining with triphenyltetrazolium chloride (TTC) was used to confirm and quantify heterogeneous microinfarct scars. The two-tailed Wilcoxon signed rank test was used to detect differences between modalities and myocardial regions.
Results: The LAD territory was 32.4% +/- 3.8 (stadard error of the mean) of the LV mass.