We close by discussing some of the likely opportunities for progress in the field.”
“Presence AZD8055 of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma(DLBCL), although this has remained controversial. The TP53 codon
72 polymorphism has shown negative impact on cancer survival, but this has not been analyzed in DLBCL. Furthermore, the MDM2 SNP309 has been associated with earlier age of onset in DLBCL. Here, we investigated the clinical impact of TP53 mutations, MDM2 SNP309 and TP53 codon 72 polymorphisms on survival in DLBCL of germinal center (GC) and non-GC subtypes. Thirteen of the 102 (12.7%) patients displayed TP53 mutations. Overall, TP53 mutations had a significant effect on lymphoma-specific survival (LSS, P = 0.009) and progression-free survival (PFS, P = 0.028). In particular, inferior survival was observed in TP53-mutated DLBCLs of GC subtype (LSS, P = 0.002 and PFS, P = 0.006). Neither MDM2 SNP309 nor the TP53 codon 72 polymorphism had an impact on age of onset or survival. Altogether, our
data suggests that TP53 mutations are associated with poor outcome in GC-DLBCL patients. (C) 2008 Elsevier Ltd. All rights reserved.”
“Objective Stattic Since 1995, Israel allows social sex selection (SxS) under certain circumstances However data regarding the attitudes of potential users are limited\n\nMethods The study population composed of a stratified sample of Israeli married men and women at the reproductive age (women aged 17-45 men aged 17-65) who had 1-2, 3, or 4+ children of the same sex\n\nWe conducted telephonic interviews with
687 Israeli residents using a structured questionnaire that included the following items demographic characteristics, opinions regarding SxS personal interest in expanding the family, and interest in choosing the sex of a future child\n\nResults Among the group of respondents who wanted to have more children (true potential users of the technology) 42 6% wished to select the sex of a future child Strong desire for family balancing was found In a multivariable logistic regression model being an ultra-orthodox was associated with a lower desire to choose (OR = 0 02 95% CI 0 01-0 06) while having more same-sex children Galardin inhibitor was associated with a greater desire to choose (OR = 3 12 95% CI 1 54-6 32)\n\nConclusions It can be estimated that if SxS were to be freely permitted in Israel, less than half of those for whom SxS is truly relevant would want to use the technology Copyright (C) 2010 John Wiley & Sons Ltd”
“Introduction: The clinical presentation of ischaemic reperfusion in postoperative patients correlates with oxidative stress. The limited clinical success of anti-ischaemic reperfusion agents has prompted a comparison of the efficacy of N-acetylcysteine (NAC) and magnesium (Mg) in South Indian patients undergoing coronary artery bypass grafting (CABG).